Best taken in between meals, or first thing in the morning or before bedtime.
This is a concentrated form of Magnesium. Some people have a low tolerance for Magnesium, please start by mixing 1/4 serving (1/8 tsp) daily into 8 ounces of water or juice and increase gradually to your comfort level. If tolerance is low, try taking your Magnesium in divided doses throughout the day instead of all at once.